Preterm birth: from understanding of pathogenesis to pregnancy management
V. S. Belousova,
A. N. Strizhakov,
E. V. Timokhina,
O. A. Svitich,
I. M. Bogomazova,
E. G. Pitskhelauri https://doi.org/10.17749/2313-7347.2018.12.4.047-051
Abstract
Preterm birth is an important issue in the current obstetrics as it is associated with perinatal morbidity and mortality. Today, most studies are aimed at understanding of the pathogenesis of preterm delivery. The known data on cytokine gene polymorphism indicate that in women with preterm birth, the presence of pro-inflammatory dominant alleles is typical. This may lead to increased production of pro-inflammatory cytokines in the utero-placental complex and may also initiate preterm delivery. At present, studies are under way to identify genes that determine the duration of the gestation period. A better understanding of the preterm birth pathogenesis is expected to help prevent this unfortunate outcome and decrease perinatal morbidity and mortality.
About the Authors
V. S. Belousova
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
PhD, Associate Professor, Department of Obstetrics, Gynecology and Perinatology, Faculty of General and Preventive Medicine
8/2 Trubetskaya St., Moscow 119991, Russia
+7(499)7823045
A. N. Strizhakov
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
MD, PhD, Professor, Academician of RAS, Head of Department of Obstetrics and Gynecology, Faculty of General and Preventive Medicine
8/2 Trubetskaya St., Moscow 119991, Russia
E. V. Timokhina
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
MD, PhD, Professor, Department of Obstetrics and Gynecology, Faculty of General and Preventive Medicine
8/2 Trubetskaya St., Moscow 119991, Russia
O. A. Svitich
Scientific Research Institute of Vaccines and Serums named after I.I. Mechnikov
Russian Federation
Russian Federation
MD, PhD, Professor, Head of Laboratory of Molecular Immunology
5А Malyi Kazennyi byst., Moscow 105064, Russia
I. M. Bogomazova
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
PhD, Associate Professor, Department of Obstetrics, Gynecology and Perinatology, Faculty of General and Preventive Medicine,
8/2 Trubetskaya St., Moscow 119991, Russia
E. G. Pitskhelauri
I.M. Sechenov First Moscow State Medical University
Russian Federation
Russian Federation
PhD, Associate Professor, Department of Obstetrics and Gynecology, Faculty of General and Preventive Medicine
8/2 Trubetskaya St., Moscow 119991, Russia
References
1. Barfield W.D. Public health implications of very preterm birth. Clin Perinatol. 2018;45(3):565–77.
2. Blencowe H., Cousens S., Chou D. et al. Born Too Soon Preterm Birth Action Group. Born too soon: the global epidemiology of 15 million preterm births. Reprod Health. 2013;10(Suppl 1):S2. DOI: 10.1186/1742-4755-10-S1-S2.
3. Wilson-Costello D., Payne A. Long-term neurodevelopmental outcomes of preterm infants: Epidemiology and risk factors. UpToDate. 2017. Available at: http://www.uptodate.com. [Accessed: 12.10.2018].
4. Di Renzo G.C., Cabero Roura L., Facchinetti F. et al. Preterm labor and birth management: Recommendations from the European Association of Perinatal Medicine. J Matern Fetal Neonatal Med. 2017;30(17):2011–30. DOI: 10.1080/14767058.2017.1323860.
5. Roberge S., Nicolaides K.H., Demers S. et al. Prevention of perinatal death and adverse perinatal outcome using low-dose aspirin: a metaanalysis. Ultrasound Obstet Gynecol. 2013;41(5):491–9.
6. Li D., Liu L., Odouli R. Presence of depressive symptoms during early pregnancy and the risk of preterm delivery: a prospective cohort study. Hum Reprod. 2009;24:146–53.
7. Dole N., Savitz D.A., Hertz-Picciotto I. et al. Maternal stress and preterm birth. Am J Epidemiol. 2003;157(1):14–24.
8. Sheiner E., Mazor-Drey E., Levy A. Asymptomatic bacteriuria during pregnancy. J Matern Fetal Neonatal Med. 2009;22(5):423–7.
9. Horton A.L., Boggess K.A. Periodontal disease and preterm birth. Obstet Gynecol Clin North Am. 2012;39(1):17–23. DOI: 10.1016/j.ogc.2011.12.008.
10. Strizhakov A.N., Belousova V.S., Svitich O.A. The clinical significance of Toll-like receptors in the pathogenesis of preterm labor. [Klinicheskoe znachenie Toll-podobnyh receptorov v patogeneze
11. prezhdevremennyh rodov]. Voprosy ginekologii, akusherstva i perinatologii. 2016;15(1):35–40 (in Russ.).
12. Strizhakov A.N., Belousova V.S., Timokhina E.V., Bogomazova I.M., Pitskhelauri E.G. Perinatal outcomes in preterm labor. [Perinatal'nye iskhody pri prezhdevremennyh rodah]. Voprosy ginekologii, akusherstva i perinatologii. 2016;15(4):7–12 (in Russ.).
13. Protonotariou E., Chrelias C., Kassanos D. et al. Immune response parameters during labor and early neonatal life. In Vivo. 2010;24(1):117–23.
14. Zhu Q., Sun J, Chen Y. Preterm birth and single nucleotide polymorphisms in cytokine genes. Transl Pediatr. 2014;3(2):120–34.
15. Settin A., Abdel-Hady H., El-Baz R., Saber I. Gene polymorphisms of TNF-α (−308), IL-10 (−1082), IL-6 (−174), and IL-1Ra (VNTR) related to susceptibility and severity of rheumatic heart disease. Pediatr Cardiol. 2007;28(5):363–71.
16. Monangi N.K., Brockway H.M., House M. et al. The genetics of preterm birth: зrogress and promise. Semin Perinatol. 2015;39(8):574-83. DOI: 10.1053/j.semperi.2015.09.005.
17. Zhang G., Srivastava A., Bacelis J. et al. Genetic studies of gestational duration and preterm birth. Best Pract Res Clin Obstet Gynaecol. 2018. pii: S1521-6934(18)30110-X. DOI: 10.1016/j.bpobgyn.2018.05.003.
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For citations:
Belousova V.S., Strizhakov A.N., Timokhina E.V., Svitich O.A., Bogomazova I.M., Pitskhelauri E.G. Preterm birth: from understanding of pathogenesis to pregnancy management. Obstetrics, Gynecology and Reproduction. 2018;12(4):47-51. (In Russ.) https://doi.org/10.17749/2313-7347.2018.12.4.047-051
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