Transient deficiency of antithrombin during pregnancy in a woman with a history of reproductive losses
https://doi.org/10.17749/2313-7347.2018.12.2.062-067
Abstract
Antithrombin deficiency is associated with a high risk of thrombotic events and obstetric complications. Even under an antithrombotic therapy, adverse pregnancy outcomes may occur. We present a case of successful pregnancy completion in a woman with newly diagnosed antithrombin deficiency and a history of miscarriages without thrombotic events. In the postpartum period, her antithrombin level restored to normal.
About the Authors
L. O. Buzyan
LLC «MedInService», Center of Reproduction and Genetics «Nova Сlinik»
Russian Federation
Russian Federation
Buzyan Lydia Olegovna – General Practitioner, Center of Reproduction and Genetics «Nova Сlinik»
33, str 4, ul. Usacheva, Moscow, 119048
V. S. Chulkov
South-Ural State Medical University, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Chulkov Vasily Sergeevich – MD, Associate Professor, Department of Unternal Medicine
64, ul. Vorovskogo, Chelyabinsk, 454092
References
1. Gaman A.M., Gaman G.D. Deficiency of antithrombin III (AT III) – case report and review of the literature. Curr Health Sci J. 2014; 40 (2): 141-3.
2. Thrombohemorrhagic complications in obstetric-gynecological practice: a guide for doctors. [Trombogemorragicheskie oslozhneniya v akushersko-ginekologicheskoj praktike: rukovodstvo dlya vrachej (Pod red. A.D. Makacariya)]. M.: MIA. 2011: 1056 s (in Russian).
3. Lippi G., Favaloro E.J. Activated partial thromboplastin time: new tricks for an old dogma. Semin Thromb Hemost. 2008; 34: 604-11.
4. Dolgushina V.F., Vereina N.K., Chulkov V.S. et al. Diagnostic and therapeutic tactics for obstetric complications associated with thrombophilia: a textbook for doctors and students of medical universities. [Diagnosticheskaya i lechebnaya taktika pri akusherskih oslozhneniyah, associirovannyh s trombofiliej: uchebnoe posobie dlya vrachej i studentov med. vuzov]. Chelyabinsk. 2015: 47 s (in Russian).
5. Di Minno M.N., Ambrosino P., Ageno W. et al. Natural anticoagulants deficiency and the risk of venous thromboembolism: a meta-analysis of observational studies. Thrombosis Research. 2015; 135 (5): 923-32.
6. Croles F.N., Nasserinejad K., Duvekot J.J. et al. Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis. BMJ. 2017; 359: j4452. DOI: 10.1136/bmj.j4452.
7. Sabadell J., Casellas M., Alijotas-Reig J. et al. Inherited antithrombin deficiency and pregnancy: maternal and fetal outcomes. Eur J Obstet Gynecol Reprod Biol. 2010; 149 (1): 47-51.
8. James A.H., Jamison M.G., Brancazio L.R. et al. Venous thromboembolism during pregnancy and the postpartum period: incidence, risk factors, and mortality. Am J Obstet Gynecol. 2006; 194 (5): 1311-5.
Review
For citations:
Buzyan L.O., Chulkov V.S. Transient deficiency of antithrombin during pregnancy in a woman with a history of reproductive losses. Obstetrics, Gynecology and Reproduction. 2018;12(2):62-67. (In Russ.) https://doi.org/10.17749/2313-7347.2018.12.2.062-067
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