GESTATIONAL TROPHOBLASTIC DISEASE: CLASSIFICATION, EPIDEMIOLOGY AND PATHOGENESIS
https://doi.org/10.17749/2313-7347.2018.12.1.093-098
Abstract
Gestational trophoblastic disease (GTD) is a cumulative name of the diseases that occur in pregnant women as a result of abnormal trophoblast proliferation. It includes benign (full or partial hydatidiform mole) and malignant (so-called gestational trophoblastic neoplasias) diseases. Statistically, the incidence of hydatidiform mole varies from region to region. That may be due to either the ethnic factors or related to a specific diet, the quality of diagnosis, representatives of the statistical data and the lack of a uniform protocol of data registration.
About the Authors
A. G. SolopovaRussian Federation
Solopova Antonina Grigorievna – MD, Professor, Department of Obstetrics and Gynecology, Faculty of Medical and Preventive Medicine.
62, str. 1, ul. Zemlyanoi Val, Moscow, 109004
A. D. Makatsariya
Russian Federation
Makatsariya Alexander Davidovich – MD, Corresponding Member of RAS, Professor, Head of Department of Obstetrics and Gynecology, Faculty of Medical and Preventive Medicine.
62, str. 1, ul. Zemlyanoi Val, Moscow, 109004
E. S. Egorova
Russian Federation
Egorova Elena Sergeevna – PhD, Associate Professor, Department of Obstetrics and Gynecology, Faculty of Medical and Preventive Medicine.
62, str. 1, ul. Zemlyanoi Val, Moscow, 109004, +7(910)4120643
V. S. Moskvichyova
Russian Federation
Moskvichyova V.S. – 6th year Medical Student, Faculty of Pediatrics.
62, str. 1, ul. Zemlyanoi Val, Moscow, 109004, +7(925)1290922
D. V. Mitryuk
Moldova, Republic of
Mitryuk Diana Viktorovna – Аssistant, Department of Obstetrics and Gynecology.
165, bul. Shtefan chel Mare, Kishinev
References
1. Seckl M.J., Sebire N.J., Berkowitz R.S. Gestational trophoblastic disease. Lancet. 2010; 376 (9742): 717-29.
2. Mangili G., Lorusso D., Brown J. et al. Trophoblastic disease review for diagnosis and management: a joint report from the International Society for the Study of Trophoblastic Disease, European Organisation for the Treatment of Trophoblastic Disease, and the Gynecologic Cancer Inter Group. Int J Gynecol Cancer. 2014; 24 (9 Suppl 3): 109-16.
3. Lurain J.R. Advances in management of high-risk gestational trophoblastic tumors. J Reprod Med. 2002; 47 (6): 451-9.
4. Seckl M.J., Sebire N.J., Fisher R.A. et al. Gestational trophoblastic disease: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2013; 24 (Suppl 6): vi39-50.
5. Lurain J.R. Gestational trophoblastic disease I: epidemiology, pathology, clinical presentation and diagnosis of gestational trophoblastic disease, and management of hydatidiform mole. Am J Obstet Gynecol. 2010; 203 (6): 531-9. DOI: 10.1016/j.ajog.2010.06.073. PMID 20728069.
6. Brown J., Naumann R.W., Seckl M.J., Schink J. et al. 15 years of progress in gestational trophoblastic disease: Scoring, standardization, and salvage. Gynecol Oncol. 2016; 144 (1): 200-7.
7. Berkowitz R.S., Goldstein D.P. Clinical practice. Molar pregnancy. N Engl J Med. 2009; 360 (16): 1639-45.
8. Smith H.O., Hilgers R.D., Bedrick E.J. et al. Ethnic differences at risk for gestational trophoblastic disease in New Mexico: a 25-year population-based study. Am J Obstet Gynecol. 2003; 188 (2): 357-66.
9. Braga A., Uberti E.M., Fajardo Mdo C. et al. Epidemiological report on the treatment of patients with gestational trophoblastic disease in 10 Brazilian referral centers: results after 12 years since International FIGO 2000 Consensus. J Reprod Med. 2014; 59 (5-6): 241-7.
10. Papadopoulos A.J., Foskett M., Seckl M.J. et al. Twenty-five years' clinical experience with placental site trophoblastic tumors. J Reprod Med. 2002; 47 (6): 460-4.
11. Schmid P., Foskett M., Seckl M.J. et al. Prognostic markers and long-term outcome of placental-site trophoblastic tumors: a retrospective observational study. Lancet. 2009; 374 (9683): 48-55.
12. Sidorova I.S., Kulakov V.I., Makarov I.O. Obstetrics guideline [Rukovodstvo po akusherstvu]. Moskva: Medicina. 2006: 1030 s (in Russian).
13. Szulman A.E., Surti U. The syndromes of hydatidiform mole: I. cytogenic and morphologic correlations. Am J Obstet Gynecol. 1997 (6); 131: 665-71.
14. Lawler S.D., Fisher R.A., Dent J. A prospective genetic study of complete and partial hydatidiform moles. Am J Obstet Gynecol. 1991; 164: 1270-7.
15. Genest D.R., Ruiz R.E., Weremowicz S. et al. Do nontriploid partial hydatidiform moles exist? J Reprod Med. 2002; 47 (5): 363-8.
16. Lage J.M. Gestational trophoblastic diseases. In: Pathology of the Female Reproductive Tract [Eds. S.J. Robboy, M.C. Anderson, P. Russell]. Edinburgh, UK: Churchill Livingstone. 2001: 759-81.
17. Shih I.M., Kurman R.J. Ki-67 labeling index in the differential diagnosis of exaggerated placental site, placental site trophoblastic tumor, and choriocarcinoma: a double immunohistochemical staining technique using Ki-67 and Mel-CAM antibodies. Hum Pathol. 1998; 29 (1): 27-33.
18. Hyman D.M., Bakios L., Gualtiere G. et al. Placental site trophoblastic tumor: analysis of presentation, treatment, and outcome. Gynecol Oncol. 2013; 129 (1): 58-62.
Review
For citations:
Solopova A.G., Makatsariya A.D., Egorova E.S., Moskvichyova V.S., Mitryuk D.V. GESTATIONAL TROPHOBLASTIC DISEASE: CLASSIFICATION, EPIDEMIOLOGY AND PATHOGENESIS. Obstetrics, Gynecology and Reproduction. 2018;12(1):93-98. (In Russ.) https://doi.org/10.17749/2313-7347.2018.12.1.093-098

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.