ANTIPHOSPHOLIPID SYNDROME AND EARLY REPRODUCTIVE FAILURE
https://doi.org/10.17749/2313-7347.2016.10.4.114-122
Abstract
Antiphospholipid antibodies by disrupting trophoblast invasion and endometrial angiogenesis might contribute to a defective placentation and, in turn, affect the successful beginning of pregnancy. It is well known and proven that these processes begin with the founding of the utero-placental blood flow. Given the ability of aPLs to affect implantation and placentation, authors have recently suggested the possibility that aPLs may be responsible also for recurrent implantation failure, early pregnancy loss and unexplained sterility. Possible pathogenic mechanisms: the ability of aPLs to exert a direct negative effect on uterine endothelium and preimplantation embryos, increased activity of NK-cells, increased prothrombotic mechanisms and disruption of the processes of fibrinolysis and fibrin formation.
About the Authors
M. I. Krivonos
Institute of Obstetrics Gynecology and Reproductive named after D.O. Ott
Russian Federation
Russian Federation
graduate student,
Mendeleevskaja linija, 3, Sankt-Peterburg, 199034
M. S. Zainulina
The first St. Petersburg State Medical University named after Academician Pavlov;
St. Petersburg health care institution "Maternity Hospital №6 them. prof. VF Snegirev"
Russian Federation
Russian Federation
MD, Professor of the Department of Obstetrics and Gynecology, ul. L'va Tolstogo, 6-8, Sankt-Peterburg, 197022;
chief physician, ul. Majakovskogo, 5, Sankt-Peterburg, 191014
S. A. Selkov
Institute of Obstetrics Gynecology and Reproductive named after D.O. Ott
Russian Federation
Russian Federation
MD, Professor, Honored Worker of Science, Head of the department of immunology and cell-cell interactions,
Mendeleevskaja linija, 3, SanktPeterburg, 199034
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Review
For citations:
Krivonos M.I., Zainulina M.S., Selkov S.A. ANTIPHOSPHOLIPID SYNDROME AND EARLY REPRODUCTIVE FAILURE. Obstetrics, Gynecology and Reproduction. 2016;10(4):114-122. (In Russ.) https://doi.org/10.17749/2313-7347.2016.10.4.114-122
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