Early neonatal sepsis caused by  Haemophilus influenzae

A. L. Karpova; A. V. Mostovoi; S. V. Martirosyan; O. E. Orlova; L. N. Karpov; A. L. Zaplatnikov

doi:10.17749/2313-7347/ob.gyn.rep.2023.415

Early neonatal sepsis caused by Haemophilus influenzae

A. L. Karpova, A. V. Mostovoi, S. V. Martirosyan, O. E. Orlova, L. N. Karpov, A. L. Zaplatnikov

https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.415

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Abstract

Neonatal sepsis still remains a serious problem of modern health care, being one of the main causes of neonatal and infant mortality, as well as disability in surviving children. Due to the high risk of adverse outcomes, the problem of early neonatal sepsis (ENS), especially in preterm infants, attracts special attention. At the same time, if in the previous decades the main causative agents of ENS were Escherichia coli and Streptococcus group B, then in recent years it has been noted that while maintaining the leading value in the etiological structure of Escherichia coli, the frequency of detection of Haemophilus influenzae began to increase. The article contains a review of modern publications on the role of Haemophilus influenzae in the formation of perinatal losses, as well as the significance of this pathogen in the development of neonatal sepsis. The article also presents a clinical case report of ENS caused by Haemophilus influenzae. Particular attention is paid to the issues of timely diagnosis of ENS, which is possible only with a comprehensive analysis of the results of clinical and laboratory-instrumental examination.

Keywords

inflammation biomarkers, infant, interleukin-6, prematurity, newborn, neutrophil index, procalcitonin, C-reactive protein, NEOMOD scale

About the Authors

A. L. Karpova

Vorokhobov City Clinical Hospital № 67, Moscow City Healthcare Department; Russian Medical Academy of Continuous Professional Education, Health Ministry of Russian Federation; Yaroslavl State Medical University, Health Ministry of Russian Federation
Russian Federation

Anna L. Karpova – MD, PhD, Intensive Care Specialist, Neonatologist, Head of Neonatal Inpatient Department; Associate Professor, Gavryushov Neonatal Department; Assistant, Department of Polyclinic Therapy, Clinical Laboratory Diagnostics and Medical Biochemistry; Member of the Board of the Russian Society of Neonatologists.

Author ID: 841410.

2/44 Salyama Adilya St., Moscow 123423;
2/1 bldg. 1, Barrikadnaya Str., Moscow 123993;
5 Revolutsionnaya Str., Yaroslavl 150000

A. V. Mostovoi

Alexei V. Mostovoi – MD, PhD, Intensive Care Specialist, Neonatologist, Head of Resuscitation and Intensive Care Service; Associate Professor, Gavryushov Neonatal Department; Assistant, Department of Polyclinic Therapy, Clinical Laboratory Diagnostics and Medical Biochemistry; Chief External Neonatologist of the Ministry of Health of the Russian Federation in the North Caucasus Federal District; Member of the Board of the Russian Society of Neonatologists; Member of the European Society for Pediatric Research (ESPR).

Scopus Author ID: 57201723894. Author ID: 636448.

2/44 Salyama Adilya St., Moscow 123423;
2/1 bldg. 1, Barrikadnaya Str., Moscow 123993;
5 Revolutsionnaya Str., Yaroslavl 150000

S. V. Martirosyan

Vorokhobov City Clinical Hospital № 67, Moscow City Healthcare Department; Lomonosov Moscow State University
Russian Federation

Sergei V. Martirosyan – MD, PhD, Deputy Chief Obstetrician; Assistant, Department of Obstetrics and Gynecology, Faculty of Fundamental Medicine

2/44 Salyama Adilya St., Moscow 123423;
1 bldg. 12, Leninskie Gory, Moscow 119234

O. E. Orlova

Vorokhobov City Clinical Hospital № 67, Moscow City Healthcare Department; Lomonosov Moscow State University
Russian Federation

Olga E. Orlova – MD, PhD (Biology), Head of Microbiological Laboratory; Associate Professor, Department of Multidisciplinary Clinical Training, Faculty of Fundamental Medicine

2/44 Salyama Adilya St., Moscow 123423;
1 bldg. 12, Leninskie Gory, Moscow 119234

L. N. Karpov

Pirogov Russian National Research Medical University, Health Ministry of Russian Federation
Russian Federation

Leonid N. Karpov – Student, International Faculty

1 Ostrovityanova Str., Moscow 117997

A. L. Zaplatnikov

Russian Medical Academy of Continuous Professional Education, Health Ministry of Russian Federation
Russian Federation

Andrey L. Zaplatnikov – MD, Dr Sci Med, Professor, Head of Gavryushov Neonatal Department; Professor, Academician Speransky Department of Pediatrics, Vice-Rector for Education

2/1 bldg. 1, Barrikadnaya Str., Moscow 123993

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Review

For citations:

Karpova A.L., Mostovoi A.V., Martirosyan S.V., Orlova O.E., Karpov L.N., Zaplatnikov A.L. Early neonatal sepsis caused by Haemophilus influenzae. Obstetrics, Gynecology and Reproduction. 2023;17(3):366-375. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2023.415

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)

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