Cognitive disorders and dementia in postmenopausal women
https://doi.org/10.17749/2313-7347/ob.gyn.rep.2022.255
Abstract
Cognitive dysfunction in postmenopausal women reduces their quality of life, social and family adaptation and can lead to complications such as dementia including Alzheimer's disease. Results of the studies on the potential of hormone replacement therapy in prevention of this group of disorders are controversial and require further investigation. However, following healthy lifestyle, certain diets as well as regular physical and mental activity can minimize the risks of dementia and ensure normal mental performance in old age.
About the Authors
I. R. Talipova
Medical Center «Razumed»
Russian Federation
Russian Federation
MD, Obstetrician-Gynecologist,
53А Yuliusa Fuchika Str., Kazan 420138
S. M. Garafieva
University of Manchester
United Kingdom
United Kingdom
Student, Faculty of Biology, Medicine and Health,
Oxford Road, Manchester M13 9PL
M. I. Mazitova
Kazan State Medical Academy – Branch of Russian Medical Academy of Continuing Professional Education, Health Ministry of Russian Federation
Russian Federation
Russian Federation
MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology,
36, Butlerova Str., Kazan 420015
R. R. Mardieva
Kazan State Medical Academy – Branch of Russian Medical Academy of Continuing Professional Education, Health Ministry of Russian Federation;
City Clinical Hospital № 7
Russian Federation
Russian Federation
MD, Assistant, Department of Obstetrics and Gynecology, 36, Butlerova Str., Kazan 420015;
Obstetrician-Gynecologist, 54 Marshala Chuikova Str., Kazan 420103
References
1. Karlamangla A.S., Lachman M.E., Han W. et al. Evidence for cognitive aging in midlife women: study of women’s health across the nation. PLoS One. 2017;12(1):e0169008. https://doi.org/10.1371/journal.pone.0169008.
2. Dementia. [Demenciya]. Vsemirnaya organizaciya zdravoohraneniya, 2020. (In Russ.). Available at: https://www.who.int/ru/news-room/fact-sheets/detail/dementia. [Accessed: 04.07.2021].
3. Lewis T.J., Trempe C. L. The end of Alzheimer's. 2nd edition. US: Academic Press, 2017. 482 p.
4. Alzheimer Association. Alzheimer's disease and dementia. Brain Tour Part 2. Available at: https://www.alz.org/alzheimers-dementia/what-isalzheimers/brain_tour_part_2. [Accessed: 04.07.2021].
5. Smits L.L., Pijnenburg Y.A., Koedam E.L. et al. Early onset Alzheimer's disease is associated with a distinct neuropsychological profile. J Alzheimers Dis. 2012;30(1):101–8. https://doi.org/10.3233/JAD-2012-111934.
6. Brewer G.J. Environmental causes and prevention measures for Alzheimer's disease. US: Academic Press, 2018. 154 p.
7. National Institute on Aging. Research & Funding. Available at: https://www.nia.nih.gov/research. [Accessed: 04.07.2021].
8. Alzheimer’s Association. Alzheimer's disease facts and figures. Alzheimers Dement. 2018;14(3):367–429.
9. Laws K.R., Irvine K., G ale T.M. Sex differences in Alzheimer's disease. Curr Opin Psychiatry. 2018;31(2):133–9. https://doi.org/10.1097/yco.0000000000000401.
10. Bekris L.M., Yu C., Bird T.D, Tsuang D.W. Genetics of Alzheimer disease. J Geriatr Psychiatry Neurol. 2010;23(4):213–27. https://doi.org/10.1177/0891988710383571.
11. Neu S.C., Pa J., Kukull W. et al. Apolipoprotein E genotype and sex risk factors for Alzheimer disease: a meta-analysis. JAMA Neurol. 2017;74(10):1178–89. https://doi.org/10.1001/jamaneurol.2017.2188.
12. Tao Y., Peters M.E., Drye L.T. et al. Sex differences in the neuropsychiatric symptoms of patients with Alzheimer's disease. Am J Alzheimers Dis Other Demen. 2018;33(7):450–7. https://doi.org/10.1177/1533317518783278.
13. Yureneva S.V., Ermakova E.I. Evaluation of the effectiveness of alternative treatments for menopausal symptoms in postmenopausal women. [Oceka effektivnosti al'ternativnyh metodov lecheniya menopauzal'nyh simptomov u zhenshchin v postmenopauze]. Medicinskij sovet. 2017;(2):76–80. (In Russ.). https://doi.org/10.21518/2079-701X-2017-2-76-80
14. Sperling R.A., Karlawish J., Johnson K.A. Preclinical Alzheimer disease – the challenges ahead. Nat Rev Neurol. 2012;9(1):54–8. https://doi.org/10.1038/nrneurol.2012.241.
15. McEwen B.S. Invited review: estrogens effects on the brain: multiple sites and molecular mechanisms. J Appl Physiol (1985). 2001;91:2785–801. https://doi.org/10.1152/jappl.2001.91.6.2785.
16. Morgan K.N., Derby C.A., Gleason C.E. Cognitive changes with reproductive aging, perimenopause, and menopause. Obstet Gynecol Clin North Am. 2018;45(4):751–63. https://doi.org/10.1016/j.ogc.2018.07.011.
17. Lin M.T, Beal M.F. Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature. 2006;443(7113):787–95. https://doi.org/10.1038/nature05292.
18. Yao J, Petanceska S.S, Montine T.J. et al. Aging, gender and APOE isotype modulate metabolism of Alzheimer's Abeta peptides and F-isoprostanes in the absence of detectable amyloid deposits. J Neurochem. 2004;90(4):1011–8. https://doi.org/10.1111/j.1471-4159.2004.02532.x.
19. Nilsen J., Irwin R.W., Gallaher T.K., Brinton R.D. Estradiol in vivo regulation of brain mitochondrial proteome. J Neurosci. 2007;27(51):14069–77. https://doi.org/10.1523/JNEUROSCI.4391-07.2007.
20. Nilsen J., Brinton R.D. Mitochondria as therapeutic targets of estrogen action in the central nervous system. Curr Drug Targets CNS Neurol Disord. 2004;3(4):297–313. https://doi.org/10.2174/1568007043337193.
21. Georgakis M. K., Beskou-Kontou T., Theodoridis I. et al. Surgical menopause in association with cognitive function and risk of dementia: a systematic review and meta-analysis. Psychoneuroendocrinology. 2019;106:9–19. https://doi.org/10.1016/j.psyneuen.2019.03.013.
22. Baber R.J., Panay N., Fenton A., IMS Writing Group. 2016 IMS Recommendations on women’s midlife health and menopause hormone therapy. Climacteric. 2016;19(2):109–150. https://doi.org/10.3109/13697137.2015.1129166.
23. Mikkola T.S., Savolainen-Peltonen H., Tuomikoski P. et al. Lower death risk for vascular dementia than for Alzheimer's disease with postmenopausal hormone therapy users. J Clin Endocrinol Metab. 2017;102(3):870–7. https://doi.org/10.1210/jc.2016-3590.
24. Imtiaz B., Tuppurainen M., Rikkonen T. Postmenopausal hormone therapy and Alzheimer disease: a prospective cohort study. Neurology. 2017;88(11):1062–8. https://doi.org/10.1212/WNL.0000000000003696.
25. Gasparyan S.A., Drosova L.D., Karpov S.M., Khripunova A.A. Use of menopausal hormone therapy in the correction of cognitive impairment in menopausal women. [Ispol'zovanie menopauzal'noj gormonal'noj terapii v korrekcii kognitivnyh narushenij u zhenshchin v klimaktericheskom periode]. Akusherstvo i ginekologiya. 2018;(12):157–62. (In Russ.). https://doi.org/10.18565/aig.2018.12.157-162.
26. Savolainen-Peltonen H., Rahkola-Soisalo P., Hoti F. et al. Use of postmenopausal hormone therapy and risk of Alzheimer's disease in Finland: nationwide case-control study. BMJ. 2019;364:l665. https://doi.org/10.1136/bmj.l665.
27. Henderson V.W, St John J.A, Hodis H.N. et al. Cognitive effects of estradiol after menopause: A randomized trial of the timing hypothesis. Neurology. 2016;87(7):699–708. https://doi.org/10.1212/WNL.000000000000298027421538.
28. Gleason C.E., Dowling N.M., Wharton W. et al. Effects of hormone therapy on cognition and mood in recently postmenopausal women: findings from the randomized, controlled KEEPS-cognitive and affective study. PLoS Med. 2015;12(6):e1001833; discussion e1001833. https://doi.org/10.1371/journal.pmed.100183326035291.
29. Espeland M.A., Shumaker S.A., Leng I. et al.; WHIMSY Study Group. Longterm effects on cognitive function of postmenopausal hormone therapy prescribed to women aged 50 to 55 years. JAMA Intern Med. 2013;173(15):1429–36. https://doi.org/10.1001/jamainternmed.2013.772723797469.
30. Menopause and climacteric state in women. Clinical guidelines. [Menopauza i klimaktericheskoe sostoyanie u zhenshchiny Klinicheskie rekomendacii]. Moscow: Rossijskoe obshchestvo akusherov-ginekologov, 2021. 86 p. (In Russ.).
31. Parfyonov V.A. Prevention and treatment of Alzheimer's disease. [Profilaktika i lechenie bolezni Al'cgejmera]. Medicinskij sovet. 2014;(18):20–6. (In Russ.).
32. Thelen M., Brown-Borg H.M. Does diet have a role in the treatment of Alzheimer's disease? Front Aging Neurosci. 2020;12:617071. https://doi.org/10.3389/fnagi.2020.617071.
33. Shi L., Chen S.-J., Ma M.-Y. et al. Sleep disturbances increase the risk of dementia: A systematic review and meta-analysis. Sleep Med Rev. 2018;40:4–16. https://doi.org/10.1016/j.smrv.2017.06.010.
34. Stephen R., Hongisto K., Solomon A., Lönnroos E. Physical activity and Alzheimer's disease: a systematic review. J Gerontol A Biol Sci Med Sci. 2017;72(6):733–9. https://doi.org/10.1093/gerona/glw251.
35. Lee J. The relationship between physical activity and dementia: a systematic review and meta-analysis of prospective cohort studies. J Gerontol Nurs. 2018;44(10):22–9. https://doi.org/10.3928/00989134-20180814-01.
36. Morris J.K., Vidoni E.D., Johnson D.K. et al. Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial. PLoS One. 2017;12(2):e0170547. https://doi.org/10.1371/journal.pone.0170547.
37. Lamb S.E., Sheehan B., Atherton N. et al. Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial. BMJ. 2018;361:k1675. https://doi.org/10.1136/bmj.k1675.
38. Brasure M., Desai P., Davila H. et al. Physical activity interventions in preventing cognitive decline and Alzheimer-type dementia: A systematic review. Ann Intern Med. 2018;168(1):30–8. https://doi.org/10.7326/M17-1528.
39. Barha C.K., Hsiung G.-Y.R., Best J.R. et al. Sex difference in aerobic exercise efficacy to improve cognition in older adults with vascular cognitive impairment: secondary analysis of a randomized controlled trial. J Alzheimers Dis. 2017;60(4):1397–410. https://doi.org/10.3233/jad-170221.
40. Petersson S.D., Philippou E. Mediterranean diet, cognitive function, and dementia: a systematic review of the evidence. Adv Nutr. 2016;7(5):889– 904. https://doi.org/10.3945/an.116.012138.
41. Yusufov M., Weyandt L.L., Piryatinsky I. Alzheimer's disease and diet: a systematic review. Int J Neurosci. 2017;127(2):161–75. https://doi.org/10. 3109/00207454.2016.1155572.
42. Radd-Vagenas S., Duffy S.L., Naismith S.L. et al. Effect of the Mediterranean diet on cognition and brain morphology and function: a systematic review of randomized controlled trials. Am J Clin Nutr. 2018;107(3):389–404. https://doi.org/10.1093/ajcn/nqx070.
43. De la Rubia Ortí J.E., García-Pardo M.P., Drehmer E. et al. Improvement of main cognitive functions in patients with Alzheimer's disease after treatment with coconut oil enriched mediterranean diet: a pilot study. J Alzheimers Dis. 2018;65(2):577–87. https://doi.org/10.3233/JAD-180184.
44. Wade A.T., Davis C.R., Dyer K.A. et al. A Mediterranean diet supplemented with dairy foods improves mood and processing speed in an Australian sample: results from the MedDairy randomized controlled trial. Nutr Neurosci. 2020;23(8):646–58. https://doi.org/10.1080/10284 15X.2018.1543148.
45. Lilamand M., Porte B., Cognat E. et al. Are ketogenic diets promising for Alzheimer's disease? A translational review. Alzheimers Res Ther. 2020;12(1):42. https://doi.org/10.1186/s13195-020-00615-4.
46. Phillips M.C.L., Deprez L.M., Mortimer G.M.N. et al. Randomized crossover trial of a modified ketogenic diet in Alzheimer's disease. Alzheimers Res Ther. 2021;13(1):51. https://doi.org/10.1186/s13195-021-00783-x.
47. Ota M., Matsuo J., Ishida I. et al. Effects of a medium-chain triglyceridebased ketogenic formula on cognitive function in patients with mild-tomoderate Alzheimer's disease. Neurosci Lett. 2019;690:232–6. https://doi.org/10.1016/j.neulet.2018.10.048.
48. Torosyan N., Sethanandha C., Grill J.D. et al. Changes in regional cerebral blood flow associated with a 45 day course of the ketogenic agent, caprylidene, in patients with mild to moderate Alzheimer's disease: Results of a randomized, double-blinded, pilot study. Exp Gerontol. 2018;111:118– 21. https://doi.org/10.1016/j.exger.2018.07.009.
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For citations:
Talipova I.R., Garafieva S.M., Mazitova M.I., Mardieva R.R. Cognitive disorders and dementia in postmenopausal women. Obstetrics, Gynecology and Reproduction. 2022;16(1):58-65. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2022.255
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